U.S. Route 101

Interstate 110 was a major North-South freeway running through Los Angeles, that led to San Pedro.

Chaos Theory
At 4:41pm, Doogie caused a deliberate car accident at Cahuenga on the 101, slowing the traffic down for the rest of the day. At 5:35pm, Jack was stuck in the traffic on the 101, and got Ryan Chappelle to send a chopper to pick him up.

Just before 8pm, Jack cornered Zapata at the intersection of the 101 and the 110, and killed him.

Day 2
The 101 was one of the major LA roads within the blast radius of the nuclear device, according to a presentation by Eric Rayburn.