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San Diego was an American city in southern California, adjacent to the international border with Mexico and the city of Tijuana. The Camp Pendleton marine base was located near the city.

Rick Allen was born in San Diego. (Findings at CTU)

The Counter Terrorist Unit operated a domestic branch, CTU San Diego, in the city. ("Day 2: 7:00pm-8:00pm")

During Day 2, Nina Myers demanded that their plane be rerouted to San Diego after she slit Mamud Rasheed Faheen's throat. ("Day 2: 3:00pm-4:00pm")

During Day 4, CTU agent Howard Bern was flown to San Diego by chopper to back up his alibi that he was not in Los Angeles during Jack Bauer's raid on the Chinese consulate there. Cheng Zhi and his operatives captured Bern shortly after he landed, and demanded to know who had led the mission so that China could bring him to justice. Bern relented after Cheng threatened to place him on The China Queen, docked at the Port of San Diego, to be secretly remanded to a labor camp in Xinjiang. ("Day 4: 5:00am-6:00am")

After Day 4, Chase Edmunds, struggling with personal losses and addiction, sent his daughter Angela to live with her aunt in San Diego. She continued to live there after Edmunds faked his death during the Day 6 nuclear attack. (Deadline)

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