Semtex was a powerful plastic explosive of Czech origin.
During Day 1, after most of Ira Gaines' crew were killed or arrested, Alexis Drazen rigged one of the group's staging areas with Semtex. When Kevin Carroll and the other survivors arrived to prepare for their escape, Drazen detonated the Semtex, killing everyone inside the building and allowing him to stroll out and execute Carroll. ("Day 1: 1:00pm-2:00pm", Findings at CTU)
Andre Drazen and his team used Semtex to blow open the door of the Saugus detention center where his father Victor was being held. ("Day 1: 8:00pm-9:00pm", Findings at CTU)